Synthesis, Characterization and Pharmacological Evaluation of 1-(2-Chloro-6-Fluorophenyl)-5-Methylindolin-2-One: A New Anti-Inflammatory Compound with Reduced Gastric Ulceration Properties

The new compound 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one (1), designed using the prodrug approach, was easily obtained in 85% yield and characterized by nuclear magnetic resonance, elemental analysis, mass spectrometry and infrared spectroscopy. The lactam 1 showed anti-inflammatory and an...

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Detalles Bibliográficos
Autores principales: dos Santos, Jean Leandro, Chelucci, Rafael, Chiquetto, Richard, Chung, Man Chin, Campos, Michel Leandro, Peccinini, Rosangela Gonçalves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259214/
https://www.ncbi.nlm.nih.gov/pubmed/21060305
http://dx.doi.org/10.3390/molecules15118039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259214/
https://www.ncbi.nlm.nih.gov/pubmed/21060305
http://dx.doi.org/10.3390/molecules15118039

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