Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity

The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohareb, Rafat M., Fleita, Daisy H., Sakka, Ola K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259419/
https://www.ncbi.nlm.nih.gov/pubmed/21187814
http://dx.doi.org/10.3390/molecules16010016
_version_ 1783374674630017024
author Mohareb, Rafat M.
Fleita, Daisy H.
Sakka, Ola K.
author_facet Mohareb, Rafat M.
Fleita, Daisy H.
Sakka, Ola K.
author_sort Mohareb, Rafat M.
collection PubMed
description The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.
format Online
Article
Text
id pubmed-6259419
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62594192018-12-07 Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity Mohareb, Rafat M. Fleita, Daisy H. Sakka, Ola K. Molecules Article The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects. MDPI 2010-12-23 /pmc/articles/PMC6259419/ /pubmed/21187814 http://dx.doi.org/10.3390/molecules16010016 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mohareb, Rafat M.
Fleita, Daisy H.
Sakka, Ola K.
Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity
title Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity
title_full Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity
title_fullStr Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity
title_full_unstemmed Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity
title_short Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity
title_sort novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259419/
https://www.ncbi.nlm.nih.gov/pubmed/21187814
http://dx.doi.org/10.3390/molecules16010016
work_keys_str_mv AT moharebrafatm novelsynthesisofhydrazidehydrazonederivativesandtheirutilizationinthesynthesisofcoumarinpyridinethiazoleandthiophenederivativeswithantitumoractivity
AT fleitadaisyh novelsynthesisofhydrazidehydrazonederivativesandtheirutilizationinthesynthesisofcoumarinpyridinethiazoleandthiophenederivativeswithantitumoractivity
AT sakkaolak novelsynthesisofhydrazidehydrazonederivativesandtheirutilizationinthesynthesisofcoumarinpyridinethiazoleandthiophenederivativeswithantitumoractivity

Ejemplares similares