Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication

Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, leading to life-threatening flaccid paralysis. Curre...

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Detalles Bibliográficos
Autores principales: Li, Bing, Peet, Norton P., Butler, Michelle M., Burnett, James C., Moir, Donald T., Bowlin, Terry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259422/
https://www.ncbi.nlm.nih.gov/pubmed/21193845
http://dx.doi.org/10.3390/molecules16010202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259422/
https://www.ncbi.nlm.nih.gov/pubmed/21193845
http://dx.doi.org/10.3390/molecules16010202

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