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Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication
Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, leading to life-threatening flaccid paralysis. Curre...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259422/ https://www.ncbi.nlm.nih.gov/pubmed/21193845 http://dx.doi.org/10.3390/molecules16010202 |
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author | Li, Bing Peet, Norton P. Butler, Michelle M. Burnett, James C. Moir, Donald T. Bowlin, Terry L. |
author_facet | Li, Bing Peet, Norton P. Butler, Michelle M. Burnett, James C. Moir, Donald T. Bowlin, Terry L. |
author_sort | Li, Bing |
collection | PubMed |
description | Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, leading to life-threatening flaccid paralysis. Currently, the only therapy for BoNT intoxication (which results in the disease state botulism) includes experimental preventative antibodies and long-term supportive care. Therefore, there is an urgent need to identify and develop inhibitors that will serve as both prophylactic agents and post-exposure ‘rescue’ therapeutics. This review focuses on recent progress to discover and develop small molecule inhibitors as therapeutic countermeasures for BoNT intoxication. |
format | Online Article Text |
id | pubmed-6259422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62594222018-12-07 Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication Li, Bing Peet, Norton P. Butler, Michelle M. Burnett, James C. Moir, Donald T. Bowlin, Terry L. Molecules Review Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, leading to life-threatening flaccid paralysis. Currently, the only therapy for BoNT intoxication (which results in the disease state botulism) includes experimental preventative antibodies and long-term supportive care. Therefore, there is an urgent need to identify and develop inhibitors that will serve as both prophylactic agents and post-exposure ‘rescue’ therapeutics. This review focuses on recent progress to discover and develop small molecule inhibitors as therapeutic countermeasures for BoNT intoxication. MDPI 2010-12-30 /pmc/articles/PMC6259422/ /pubmed/21193845 http://dx.doi.org/10.3390/molecules16010202 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Li, Bing Peet, Norton P. Butler, Michelle M. Burnett, James C. Moir, Donald T. Bowlin, Terry L. Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication |
title | Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication |
title_full | Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication |
title_fullStr | Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication |
title_full_unstemmed | Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication |
title_short | Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication |
title_sort | small molecule inhibitors as countermeasures for botulinum neurotoxin intoxication |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259422/ https://www.ncbi.nlm.nih.gov/pubmed/21193845 http://dx.doi.org/10.3390/molecules16010202 |
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