The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase

DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme...

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Detalles Bibliográficos
Autores principales: Blenn, Christian, Wyrsch, Philippe, Althaus, Felix R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259645/
https://www.ncbi.nlm.nih.gov/pubmed/21343889
http://dx.doi.org/10.3390/molecules16021854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259645/
https://www.ncbi.nlm.nih.gov/pubmed/21343889
http://dx.doi.org/10.3390/molecules16021854

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