The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase

DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme...

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Detalles Bibliográficos
Autores principales: Blenn, Christian, Wyrsch, Philippe, Althaus, Felix R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259645/
https://www.ncbi.nlm.nih.gov/pubmed/21343889
http://dx.doi.org/10.3390/molecules16021854
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author Blenn, Christian
Wyrsch, Philippe
Althaus, Felix R.
author_facet Blenn, Christian
Wyrsch, Philippe
Althaus, Felix R.
author_sort Blenn, Christian
collection PubMed
description DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.
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spelling pubmed-62596452018-12-20 The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase Blenn, Christian Wyrsch, Philippe Althaus, Felix R. Molecules Review DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling. MDPI 2011-02-22 /pmc/articles/PMC6259645/ /pubmed/21343889 http://dx.doi.org/10.3390/molecules16021854 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Blenn, Christian
Wyrsch, Philippe
Althaus, Felix R.
The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
title The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
title_full The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
title_fullStr The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
title_full_unstemmed The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
title_short The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
title_sort ups and downs of tannins as inhibitors of poly(adp-ribose)glycohydrolase
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259645/
https://www.ncbi.nlm.nih.gov/pubmed/21343889
http://dx.doi.org/10.3390/molecules16021854
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