Investigation of Solvolysis Kinetics of New Synthesized Fluocinolone Acetonide C-21 Esters—An In Vitro Model for Prodrug Activation

In this study the solvolysis of newly synthesized fluocinolone acetonide C-21 esters was analysed in comparison with fluocinonide during a 24-hour period of time. The solvolysis was performed in an ethanol-water (90:10 v/v) mixture using the excess of NaHCO(3). The solvolytic mixtures of each invest...

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Detalles Bibliográficos
Autores principales: Markovic, Bojan D., Dobricic, Vladimir D., Vladimirov, Sote M., Cudina, Olivera A., Savic, Vladimir M., Karljikovic-Rajic, Katarina D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259744/
https://www.ncbi.nlm.nih.gov/pubmed/21441868
http://dx.doi.org/10.3390/molecules16032658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259744/
https://www.ncbi.nlm.nih.gov/pubmed/21441868
http://dx.doi.org/10.3390/molecules16032658

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