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Prediction of the Closed Conformation and Insights into the Mechanism of the Membrane Enzyme LpxR
Covalent modification of outer membrane lipids of Gram-negative bacteria can impact the ability of the bacterium to develop resistance to antibiotics as well as modulating the immune response of the host. The enzyme LpxR from Salmonella typhimurium is known to deacylate lipopolysaccharide molecules...
Autores principales: | Saunders, Graham M., Bruce Macdonald, Hannah E., Essex, Jonathan W., Khalid, Syma |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260217/ https://www.ncbi.nlm.nih.gov/pubmed/30287112 http://dx.doi.org/10.1016/j.bpj.2018.09.002 |
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