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Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblasts

Control of bacterial infection-induced inflammatory responses is one of the effective therapeutic approaches of periodontal diseases. Natural products such as lipid mediators and metabolites from microorganisms have been used for decreasing inflammation. We previously reported that (+)-terrein inhib...

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Detalles Bibliográficos
Autores principales: Yamamoto, Satoshi, Omori, Kazuhiro, Mandai, Hiroki, Nakayama, Masaaki, Nakagawa, Saki, Kobayashi, Hiroya, Kunimine, Tadashi, Yoshimura, Hiroshi, Sakaida, Kyosuke, Sako, Hidefumi, Ibaragi, Soichiro, Yamamoto, Tadashi, Maeda, Hiroshi, Suga, Seiji, Takashiba, Shogo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260243/
https://www.ncbi.nlm.nih.gov/pubmed/30519664
http://dx.doi.org/10.1016/j.heliyon.2018.e00979