Novel plant inducers of PXR-dependent cytochrome P450 3A4 expression in HepG2 cells

The cytochrome P450 3A4 (CYP3A4) is the most abundant CYP450 enzyme involved in the metabolism of endogenous products and xenobiotics, including prescription drugs and herbals. Modulation of hepatic CYP3A4 gene expression via nuclear receptors, like pregnane X receptor (PXR), is a major cause of adv...

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Detalles Bibliográficos
Autores principales: Al-Dosari, Mohammed S., Parvez, Mohammad K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260467/
https://www.ncbi.nlm.nih.gov/pubmed/30532626
http://dx.doi.org/10.1016/j.jsps.2018.05.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260467/
https://www.ncbi.nlm.nih.gov/pubmed/30532626
http://dx.doi.org/10.1016/j.jsps.2018.05.016

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