General Pathway for a Convenient One-Pot Synthesis of Trifluoromethyl-Containing 2-amino-7-alkyl(aryl/heteroaryl)-1,8-naphthyridines and Fused Cycloalkane Analogues

A convenient and general method for the synthesis in 26–73% yields of a new series of 7-alkyl(aryl/heteroaryl)-2-amino-5-trifluoromethyl-1,8-naphthyridines from direct cyclocondensation reactions of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones [CF(3)C(O)CH=C(R(1))OR, where R(1 )= H, Me, Ph, 4-MePh, 4-OMe...

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Detalles Bibliográficos
Autores principales: Bonacorso, Helio G., Andrighetto, Rosália, Krüger, Nícolas, Zanatta, Nilo, Martins, Marcos A. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260629/
https://www.ncbi.nlm.nih.gov/pubmed/21455095
http://dx.doi.org/10.3390/molecules16042817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260629/
https://www.ncbi.nlm.nih.gov/pubmed/21455095
http://dx.doi.org/10.3390/molecules16042817

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