Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge

Microglia are the resident innate immune cells of the central nervous system. Limited turnover throughout the lifespan leaves microglia susceptible to age-associated dysfunction. Indeed, we and others have reported microglia develop a pro-inflammatory or “primed” profile with age, characterized by i...

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Detalles Bibliográficos
Autores principales: O’Neil, Shane M., Witcher, Kristina G., McKim, Daniel B., Godbout, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260864/
https://www.ncbi.nlm.nih.gov/pubmed/30477578
http://dx.doi.org/10.1186/s40478-018-0636-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260864/
https://www.ncbi.nlm.nih.gov/pubmed/30477578
http://dx.doi.org/10.1186/s40478-018-0636-8

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