Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

Microglia, the resident immune cell of the brain, can be eliminated via pharmacological inhibition of the colony‐stimulating factor 1 receptor (CSF1R). Withdrawal of CSF1R inhibition then stimulates microglial repopulation, effectively replacing the microglial compartment. In the aged brain, microgl...

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Detalles Bibliográficos
Autores principales: Elmore, Monica R. P., Hohsfield, Lindsay A., Kramár, Enikö A., Soreq, Lilach, Lee, Rafael J., Pham, Stephanie T., Najafi, Allison R., Spangenberg, Elizabeth E., Wood, Marcelo A., West, Brian L., Green, Kim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260908/
https://www.ncbi.nlm.nih.gov/pubmed/30276955
http://dx.doi.org/10.1111/acel.12832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260908/
https://www.ncbi.nlm.nih.gov/pubmed/30276955
http://dx.doi.org/10.1111/acel.12832

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