Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

Pericentromeric satellite repeats are enriched in 5-methylcytosine (5mC). Loss of 5mC at these sequences is common in cancer and is a hallmark of Immunodeficiency, Centromere and Facial abnormalities (ICF) syndrome. While the general importance of 5mC is well-established, the specific functions of 5...

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Detalles Bibliográficos
Autores principales: Rajshekar, Srivarsha, Yao, Jun, Arnold, Paige K, Payne, Sara G, Zhang, Yinwen, Bowman, Teresa V, Schmitz, Robert J, Edwards, John R, Goll, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261255/
https://www.ncbi.nlm.nih.gov/pubmed/30484769
http://dx.doi.org/10.7554/eLife.39658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261255/
https://www.ncbi.nlm.nih.gov/pubmed/30484769
http://dx.doi.org/10.7554/eLife.39658

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