Cargando…

Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

Pericentromeric satellite repeats are enriched in 5-methylcytosine (5mC). Loss of 5mC at these sequences is common in cancer and is a hallmark of Immunodeficiency, Centromere and Facial abnormalities (ICF) syndrome. While the general importance of 5mC is well-established, the specific functions of 5...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajshekar, Srivarsha, Yao, Jun, Arnold, Paige K, Payne, Sara G, Zhang, Yinwen, Bowman, Teresa V, Schmitz, Robert J, Edwards, John R, Goll, Mary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261255/ https://www.ncbi.nlm.nih.gov/pubmed/30484769 http://dx.doi.org/10.7554/eLife.39658

Ejemplares similares

Epimutations are associated with CHROMOMETHYLASE 3-induced de novo DNA methylation
por: Wendte, Jered M, et al.
Publicado: (2019)

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome
por: Lim, Yoong Wearn, et al.
Publicado: (2015)

The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells
por: Detilleux, Dylane, et al.
Publicado: (2022)

MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response
por: Witteveldt, Jeroen, et al.
Publicado: (2019)

Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus
por: Kleijwegt, Constance, et al.
Publicado: (2023)

Asymmetry between the two acidic patches dictates the direction of nucleosome sliding by the ISWI chromatin remodeler
por: Levendosky, Robert F, et al.
Publicado: (2019)

Trisomy 21 consistently activates the interferon response
por: Sullivan, Kelly D, et al.
Publicado: (2016)

A common bacterial metabolite elicits prion-based bypass of glucose repression
por: Garcia, David M, et al.
Publicado: (2016)

Signaling a link between interferon and the traits of Down syndrome
por: Kirsammer, Gina, et al.
Publicado: (2016)

Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition
por: Hsu, Emily, et al.
Publicado: (2021)

TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response
por: Andreev, Dmitry E, et al.
Publicado: (2018)

Dynamics of genomic innovation in the unicellular ancestry of animals
por: Grau-Bové, Xavier, et al.
Publicado: (2017)

Genome-Wide DNA Methylation Analysis Identifies Novel Hypomethylated Non-Pericentromeric Genes with Potential Clinical Implications in ICF Syndrome
por: Simo-Riudalbas, L., et al.
Publicado: (2015)

Proteins pinpoint double strand breaks
por: Cox, Michael M
Publicado: (2013)

The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress
por: Wakida, Takeshi, et al.
Publicado: (2017)

Conserved noncoding transcription and core promoter regulatory code in early Drosophila development
por: Batut, Philippe J, et al.
Publicado: (2017)

Telomere repeats induce domains of H3K27 methylation in Neurospora
por: Jamieson, Kirsty, et al.
Publicado: (2018)

Cis-regulatory evolution integrated the Bric-à-brac transcription factors into a novel fruit fly gene regulatory network
por: Roeske, Maxwell J, et al.
Publicado: (2018)

The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology
por: Fu, Yu, et al.
Publicado: (2018)

High levels of histones promote whole-genome-duplications and trigger a Swe1(WEE1)-dependent phosphorylation of Cdc28(CDK1)
por: Maya Miles, Douglas, et al.
Publicado: (2018)

NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins
por: Campbell, Amy E, et al.
Publicado: (2018)

Codon choice directs constitutive mRNA levels in trypanosomes
por: de Freitas Nascimento, Janaina, et al.
Publicado: (2018)

MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion
por: Zheng, Ge, et al.
Publicado: (2018)

Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice
por: Gregorova, Sona, et al.
Publicado: (2018)

A gene-specific T2A-GAL4 library for Drosophila
por: Lee, Pei-Tseng, et al.
Publicado: (2018)

CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape
por: Howe, Françoise S, et al.
Publicado: (2017)

A quantitative hypermorphic CNGC allele confers ectopic calcium flux and impairs cellular development
por: Chiasson, David M, et al.
Publicado: (2017)

Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria
por: Quin, Jaclyn E, et al.
Publicado: (2017)

Transcription of a 5’ extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter
por: Chia, Minghao, et al.
Publicado: (2017)

Kinetochore inactivation by expression of a repressive mRNA
por: Chen, Jingxun, et al.
Publicado: (2017)

RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit
por: Milligan, Laura, et al.
Publicado: (2017)

Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription
por: Zhou, Zhen, et al.
Publicado: (2017)

Rapid DNA replication origin licensing protects stem cell pluripotency
por: Matson, Jacob Peter, et al.
Publicado: (2017)

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
por: Altemose, Nicolas, et al.
Publicado: (2017)

Efficient termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance
por: du Mee, Dorine Jeanne Mariëtte, et al.
Publicado: (2018)

YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci
por: Shichino, Yuichi, et al.
Publicado: (2018)

Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis
por: Phizicky, David V, et al.
Publicado: (2018)

Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq
por: Claussin, Clémence, et al.
Publicado: (2017)

Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo
por: Stadler, Michael R, et al.
Publicado: (2017)

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
por: Povedano, Juan Manuel, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_sdhdrbhp002j8rnqgg71pohd45