Synthetic STARR-seq reveals how DNA shape and sequence modulate transcriptional output and noise

The binding of transcription factors to short recognition sequences plays a pivotal role in controlling the expression of genes. The sequence and shape characteristics of binding sites influence DNA binding specificity and have also been implicated in modulating the activity of transcription factors...

Descripción completa

Detalles Bibliográficos
Autores principales: Schöne, Stefanie, Bothe, Melissa, Einfeldt, Edda, Borschiwer, Marina, Benner, Philipp, Vingron, Martin, Thomas-Chollier, Morgane, Meijsing, Sebastiaan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261644/
https://www.ncbi.nlm.nih.gov/pubmed/30427832
http://dx.doi.org/10.1371/journal.pgen.1007793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261644/
https://www.ncbi.nlm.nih.gov/pubmed/30427832
http://dx.doi.org/10.1371/journal.pgen.1007793

Ejemplares similares