Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing

In females with X-linked genetic disorders, wild-type and mutant cells coexist within brain tissue because of X-chromosome inactivation, posing challenges for interpreting the effects of X-linked mutant alleles on gene expression. We present a single-nucleus RNA sequencing approach that resolves mos...

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Detalles Bibliográficos
Autores principales: Renthal, William, Boxer, Lisa D., Hrvatin, Sinisa, Li, Emmy, Silberfeld, Andrew, Nagy, M. Aurel, Griffith, Eric C., Vierbuchen, Thomas, Greenberg, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261686/
https://www.ncbi.nlm.nih.gov/pubmed/30455458
http://dx.doi.org/10.1038/s41593-018-0270-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261686/
https://www.ncbi.nlm.nih.gov/pubmed/30455458
http://dx.doi.org/10.1038/s41593-018-0270-6

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