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Interactive calculator for operating characteristics of phase I cancer clinical trials using standard 3+3 designs

Among various Phase I clinical trial designs, rule-based standard 3 + 3 designs are the most widely utilized for their simplicity and robustness. It is necessary to define crucial operating characteristics of a Phase I clinical trial before it starts. Based on the assumed probability of dose limitin...

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Detalles Bibliográficos
Autores principales: Chen, Zhengjia, Zheng, Youyun, Wang, Zhibo, Kutner, Michael, Curran, Walter J., Kowalski, Jeanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261803/
https://www.ncbi.nlm.nih.gov/pubmed/30533550
http://dx.doi.org/10.1016/j.conctc.2018.10.006