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The roles of prostaglandin F(2) in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes
Osteoarthritis (OA) was recently identified as being regulated by the induction of cyclooxygenase-2 (COX-2) in response to high fluid shear stress. Although the metabolic products of COX-2, including prostaglandin (PG)E(2), 15-deoxy-Δ(12,14)-PGJ(2) (15d-PGJ(2)), and PGF(2α), have been reported to be...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261940/ https://www.ncbi.nlm.nih.gov/pubmed/30510777 http://dx.doi.org/10.1038/s41392-018-0029-2 |