PDI Knockdown Inhibits Seizure Activity in Acute Seizure and Chronic Epilepsy Rat Models via S-Nitrosylation-Independent Thiolation on NMDA Receptor

Redox modulation and S-nitrosylation of cysteine residues are the post-translational modifications of N-methyl-D-aspartate receptor (NMDAR) to regulate its functionality. Recently, we have reported that protein disulfide isomerase (PDI) reduces disulfide bond (S-S) to free thiol (-SH) on NMDAR. Sinc...

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Detalles Bibliográficos
Autores principales: Jeon, A. Ran, Kim, Ji-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261974/
https://www.ncbi.nlm.nih.gov/pubmed/30524244
http://dx.doi.org/10.3389/fncel.2018.00438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261974/
https://www.ncbi.nlm.nih.gov/pubmed/30524244
http://dx.doi.org/10.3389/fncel.2018.00438

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