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A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation
Inflammatory diseases of the pancreas have no specific therapy. Discovery of the genetic basis of chronic pancreatitis identified the digestive enzyme trypsin as a therapeutic target. Preclinical testing of trypsin inhibition has been hampered by the lack of animal models. Here we report the T7D23A...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261995/ https://www.ncbi.nlm.nih.gov/pubmed/30487519 http://dx.doi.org/10.1038/s41467-018-07347-y |