Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown

Mutations in the endosome-associated protein CHMP2B cause frontotemporal dementia and lead to lysosomal storage pathology in neurons. We here report that physiological levels of mutant CHMP2B causes reduced numbers and significantly impaired trafficking of endolysosomes within neuronal dendrites, ac...

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Detalles Bibliográficos
Autores principales: Clayton, Emma L, Milioto, Carmelo, Muralidharan, Bhavana, Norona, Frances E, Edgar, James R, Soriano, Armand, Jafar-nejad, Paymaan, Rigo, Frank, Collinge, John, Isaacs, Adrian M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262218/
https://www.ncbi.nlm.nih.gov/pubmed/30496365
http://dx.doi.org/10.1093/brain/awy284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262218/
https://www.ncbi.nlm.nih.gov/pubmed/30496365
http://dx.doi.org/10.1093/brain/awy284

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