Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents

Specific modifications of colchicine followed by synthesis of its analogues have been tested in vitro with the objective of lowering colchicine toxicity. Our previous studies have clearly shown the anticancer potential of double-modified colchicine derivatives in C-7 and C-10 positions. Here, a seri...

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Detalles Bibliográficos
Autores principales: Majcher, Urszula, Klejborowska, Greta, Kaik, Magdalena, Maj, Ewa, Wietrzyk, Joanna, Moshari, Mahshad, Preto, Jordane, Tuszynski, Jack A., Huczyński, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262455/
https://www.ncbi.nlm.nih.gov/pubmed/30463236
http://dx.doi.org/10.3390/cells7110216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262455/
https://www.ncbi.nlm.nih.gov/pubmed/30463236
http://dx.doi.org/10.3390/cells7110216

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