The Intermolecular Interaction of Ephexin4 Leads to Autoinhibition by Impeding Binding of RhoG

Ephexin4 is a guanine nucleotide-exchange factor (GEF) for RhoG and is involved in various RhoG-related cellular processes such as phagocytosis of apoptotic cells and migration of cancer cells. Ephexin4 forms an oligomer via an intermolecular interaction, and its GEF activity is increased in the pre...

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Detalles Bibliográficos
Autores principales: Kim, Kwanhyeong, Lee, Juyeon, Moon, Hyunji, Lee, Sang-Ah, Kim, Deokhwan, Yang, Susumin, Lee, Dae-Hee, Lee, Gwangrog, Park, Daeho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262623/
https://www.ncbi.nlm.nih.gov/pubmed/30445756
http://dx.doi.org/10.3390/cells7110211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262623/
https://www.ncbi.nlm.nih.gov/pubmed/30445756
http://dx.doi.org/10.3390/cells7110211

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