The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts

Mitochondrial DNA mutations accumulate with age and may play a role in stem cell aging as suggested by the premature aging phenotype of mitochondrial DNA polymerase gamma (POLG) exonuclease-deficient mice. Therefore, E1A immortalized murine embryonic fibroblasts (MEFs) from POLG exonuclease-deficien...

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Detalles Bibliográficos
Autores principales: Delic, Vedad, Noble, Kenyaria, Zivkovic, Sandra, Phan, Tam-Anh, Reynes, Christian, Zhang, Yumeng, Phillips, Oluwakemi, Claybaker, Charles, Ta, Yen, Dinh, Vinh B., Cruz, Josean, Prolla, Tomas A., Bradshaw, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262855/
https://www.ncbi.nlm.nih.gov/pubmed/30177551
http://dx.doi.org/10.1242/bio.033852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262855/
https://www.ncbi.nlm.nih.gov/pubmed/30177551
http://dx.doi.org/10.1242/bio.033852

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