Cargando…

Chemistry and Structure-Activity Relationship of the Styrylquinoline-Type HIV Integrase Inhibitors

In spite of significant progress in anti-HIV-1 therapy, current antiviral chemo-therapy still suffers from deleterious side effects and emerging drug resistance. Therefore, the development of novel antiviral drugs remains a crucial issue for the fight against AIDS. HIV-1 integrase is a key enzyme in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mouscadet, Jean-François, Desmaële, Didier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263292/ https://www.ncbi.nlm.nih.gov/pubmed/20657464 http://dx.doi.org/10.3390/molecules15053048

Ejemplares similares

Integrase and integration: biochemical activities of HIV-1 integrase
por: Delelis, Olivier, et al.
Publicado: (2008)

In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors
por: Ni, Xiaoju, et al.
Publicado: (2012)

Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives
por: Jiao, Zi-Guo, et al.
Publicado: (2010)

A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles
por: Delelis, Olivier, et al.
Publicado: (2005)

Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An in silico analysis
por: Hutapea, Hotma Martogi Lorensi, et al.
Publicado: (2018)

Patterns of resistance development with integrase inhibitors in HIV
por: Mbisa, Jean L, et al.
Publicado: (2011)

Spectroscopic Studies of Styrylquinoline Copolymers with Different Substituents
por: Sypniewska, Malgorzata, et al.
Publicado: (2022)

Efficient and Specific Internal Cleavage of a Retroviral Palindromic DNA Sequence by Tetrameric HIV-1 Integrase
por: Delelis, Olivier, et al.
Publicado: (2007)

Synthesis and evaluation of the in vitro and in vivo antitrypanosomal activity of 2-styrylquinolines
por: Espinosa, Roger, et al.
Publicado: (2021)

A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain
por: Carayon, Kevin, et al.
Publicado: (2010)

Raltegravir: first in class HIV integrase inhibitor
por: Temesgen, Zelalem, et al.
Publicado: (2008)

Integrase Strand Transfer Inhibitors in HIV Therapy
por: Mesplède, Thibault, et al.
Publicado: (2013)

Synthesis, and spectroscopic and structural characterization of three new styrylquinoline–benzimidazole hybrids
por: Ardila, Diana M., et al.
Publicado: (2022)

HIV-1 Reverse Transcriptase/Integrase Dual Inhibitors: A Review of Recent Advances and Structure-activity Relationship Studies
por: Mahboubi-Rabbani, Mohammad, et al.
Publicado: (2021)

Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase
por: Gupta, Kushol, et al.
Publicado: (2016)

HIV-1 Integrase Strand Transfer Inhibitors and Neurodevelopment
por: Foster, Emma G., et al.
Publicado: (2022)

Progress in HIV-1 Integrase Inhibitors: A Review of their Chemical Structure Diversity
por: Hajimahdi, Zahra, et al.
Publicado: (2016)

Resistance to Integrase Inhibitors
por: Métifiot, Mathieu, et al.
Publicado: (2010)

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors
por: Zhao, Xue Zhi, et al.
Publicado: (2017)

Impact of the HIV integrase genetic context on the phenotypic expression and in vivo dynamics of integrase inhibitor resistance mutations
por: Nguyen, Nga, et al.
Publicado: (2013)

The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation
por: Delelis, Olivier, et al.
Publicado: (2009)

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action
por: Mrozek-Wilczkiewicz, Anna, et al.
Publicado: (2015)

G140S/Q148R and N155H mutations render HIV-2 Integrase resistant to Raltegravir whereas Y143C does not
por: Ni, Xiao-Ju, et al.
Publicado: (2011)

Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
por: El-Sayed, Magda A.-A., et al.
Publicado: (2017)

HIV drug resistance against strand transfer integrase inhibitors
por: Anstett, Kaitlin, et al.
Publicado: (2017)

Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs
por: Smith, Steven J., et al.
Publicado: (2021)

Multiple choices for HIV therapy with integrase strand transfer inhibitors
por: Raffi, Francois, et al.
Publicado: (2012)

Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase
por: Bonnard, Damien, et al.
Publicado: (2023)

Integrase Inhibitor Prodrugs: Approaches to Enhancing the Anti-HIV Activity of β-Diketo Acids
por: Nair, Vasu, et al.
Publicado: (2015)

Design, Synthesis and Structure-activity Studies of Rhodanine Derivatives as HIV-1 Integrase Inhibitors
por: Ramkumar, Kavya, et al.
Publicado: (2010)

In vitro activity of dolutegravir against wild-type and integrase inhibitor-resistant HIV-2
por: Smith, Robert A, et al.
Publicado: (2015)

Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor
por: Nilavar, Namrata M., et al.
Publicado: (2020)

HIV-2 Integrase Variation in Integrase Inhibitor-Naïve Adults in Senegal, West Africa
por: Gottlieb, Geoffrey S., et al.
Publicado: (2011)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
por: Koneru, Pratibha C, et al.
Publicado: (2019)

Complex Relationships between HIV-1 Integrase and Its Cellular Partners
por: Rozina, Anna, et al.
Publicado: (2022)

Update on Adverse Effects of HIV Integrase Inhibitors
por: Kolakowska, Agnieszka, et al.
Publicado: (2019)

Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence
por: Mesplède, Thibault, et al.
Publicado: (2015)

Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
por: Choi, Eungi, et al.
Publicado: (2018)

Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV
por: Himmel, Daniel M., et al.
Publicado: (2020)

Characterization of natural polymorphic sites of the HIV-1 integrase before the introduction of HIV-1 integrase inhibitors in Germany
por: Meixenberger, Karolin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ov0t3ro8atvdpqc8bvrh9mogr1