Receiver Operating Characteristic Analysis and Clinical Trial Simulation to Inform Dose Titration Decisions

Optimal dose selection in clinical trials is problematic when efficacious and toxic concentrations are close. A novel quantitative approach follows for optimizing dose titration in clinical trials. A system of pharmacokinetics (PK), pharmacodynamics, efficacy, and toxicity was simulated for scenario...

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Detalles Bibliográficos
Autores principales: Clements, John David, Perez Ruixo, Juan Jose, Gibbs, John P., Doshi, Sameer, Perez Ruixo, Carlos, Melhem, Murad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263661/
https://www.ncbi.nlm.nih.gov/pubmed/30246497
http://dx.doi.org/10.1002/psp4.12354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263661/
https://www.ncbi.nlm.nih.gov/pubmed/30246497
http://dx.doi.org/10.1002/psp4.12354

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