Quantitative Systems Pharmacology Model for Alzheimer Disease Indicates Targeting Sphingolipid Dysregulation as Potential Treatment Option

Alzheimer disease (AD) is a devastating neurodegenerative disorder with high unmet medical need. Drug development is hampered by limited understanding of the disease and its driving factors. Quantitative Systems Pharmacology (QSP) modeling provides a comprehensive quantitative framework to evaluate...

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Detalles Bibliográficos
Autores principales: Clausznitzer, Diana, Pichardo‐Almarza, Cesar, Relo, Ana Lucia, van Bergeijk, Jeroen, van der Kam, Elizabeth, Laplanche, Loic, Benson, Neil, Nijsen, Marjoleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263662/
https://www.ncbi.nlm.nih.gov/pubmed/30207429
http://dx.doi.org/10.1002/psp4.12351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263662/
https://www.ncbi.nlm.nih.gov/pubmed/30207429
http://dx.doi.org/10.1002/psp4.12351

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