PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

The aim of the present study was to establish a physiologically based pharmacokinetic (PBPK) model for coproporphyrin I (CP‐I), a biomarker supporting the prediction of drug‐drug interactions (DDIs) involving hepatic organic anion transporting polypeptide 1B (OATP1B), using clinical DDI data with an...

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Detalles Bibliográficos
Autores principales: Yoshikado, Takashi, Toshimoto, Kota, Maeda, Kazuya, Kusuhara, Hiroyuki, Kimoto, Emi, Rodrigues, A. David, Chiba, Koji, Sugiyama, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263667/
https://www.ncbi.nlm.nih.gov/pubmed/30175555
http://dx.doi.org/10.1002/psp4.12348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263667/
https://www.ncbi.nlm.nih.gov/pubmed/30175555
http://dx.doi.org/10.1002/psp4.12348

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