Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1(p150)

The interferon (IFN)-mediated innate immune response is the first line of defense against viruses. However, an IFN-stimulated gene, the adenosine deaminase acting on RNA 1 (ADAR1), favors the replication of several viruses. ADAR1 binds double-stranded RNA and converts adenosine to inosine by deamina...

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Detalles Bibliográficos
Autores principales: Pfaller, Christian K., Donohue, Ryan C., Nersisyan, Stepan, Brodsky, Leonid, Cattaneo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264153/
https://www.ncbi.nlm.nih.gov/pubmed/30496178
http://dx.doi.org/10.1371/journal.pbio.2006577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264153/
https://www.ncbi.nlm.nih.gov/pubmed/30496178
http://dx.doi.org/10.1371/journal.pbio.2006577

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