Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The...

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Detalles Bibliográficos
Autores principales: Xie, Yong-Mei, Yao, Yu-Qin, Sun, Hong-Bao, Yan, Ting-Ting, Liu, Jie, Kang, Tai-Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264231/
http://dx.doi.org/10.3390/molecules16108745
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author Xie, Yong-Mei
Yao, Yu-Qin
Sun, Hong-Bao
Yan, Ting-Ting
Liu, Jie
Kang, Tai-Ran
author_facet Xie, Yong-Mei
Yao, Yu-Qin
Sun, Hong-Bao
Yan, Ting-Ting
Liu, Jie
Kang, Tai-Ran
author_sort Xie, Yong-Mei
collection PubMed
description An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
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spelling pubmed-62642312018-12-10 Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction Xie, Yong-Mei Yao, Yu-Qin Sun, Hong-Bao Yan, Ting-Ting Liu, Jie Kang, Tai-Ran Molecules Article An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity. MDPI 2011-10-19 /pmc/articles/PMC6264231/ http://dx.doi.org/10.3390/molecules16108745 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xie, Yong-Mei
Yao, Yu-Qin
Sun, Hong-Bao
Yan, Ting-Ting
Liu, Jie
Kang, Tai-Ran
Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
title Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
title_full Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
title_fullStr Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
title_full_unstemmed Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
title_short Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
title_sort facile synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition reaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264231/
http://dx.doi.org/10.3390/molecules16108745
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