Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block

A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C ra...

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Detalles Bibliográficos
Autores principales: Levi, Lucilla, Boersch, Christina, Gers, Charlotte F., Merkul, Eugen, Müller, Thomas J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264257/
https://www.ncbi.nlm.nih.gov/pubmed/22064273
http://dx.doi.org/10.3390/molecules16119340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264257/
https://www.ncbi.nlm.nih.gov/pubmed/22064273
http://dx.doi.org/10.3390/molecules16119340

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