Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block

A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C ra...

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Detalles Bibliográficos
Autores principales: Levi, Lucilla, Boersch, Christina, Gers, Charlotte F., Merkul, Eugen, Müller, Thomas J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264257/
https://www.ncbi.nlm.nih.gov/pubmed/22064273
http://dx.doi.org/10.3390/molecules16119340
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author Levi, Lucilla
Boersch, Christina
Gers, Charlotte F.
Merkul, Eugen
Müller, Thomas J. J.
author_facet Levi, Lucilla
Boersch, Christina
Gers, Charlotte F.
Merkul, Eugen
Müller, Thomas J. J.
author_sort Levi, Lucilla
collection PubMed
description A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C rapidly furnishes the title compounds in a one-pot fashion.
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spelling pubmed-62642572018-12-10 Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block Levi, Lucilla Boersch, Christina Gers, Charlotte F. Merkul, Eugen Müller, Thomas J. J. Molecules Communication A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C rapidly furnishes the title compounds in a one-pot fashion. MDPI 2011-11-07 /pmc/articles/PMC6264257/ /pubmed/22064273 http://dx.doi.org/10.3390/molecules16119340 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Levi, Lucilla
Boersch, Christina
Gers, Charlotte F.
Merkul, Eugen
Müller, Thomas J. J.
Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block
title Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block
title_full Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block
title_fullStr Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block
title_full_unstemmed Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block
title_short Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block
title_sort consecutive three-component synthesis of 3-(hetero)aryl-1h-pyrazoles with propynal diethylacetal as a three-carbon building block
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264257/
https://www.ncbi.nlm.nih.gov/pubmed/22064273
http://dx.doi.org/10.3390/molecules16119340
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