Cargando…

Synthesis and Antimalarial Activity of Novel Dihydro-Artemisinin Derivatives

The Plasmodium falciparum cysteine protease falcipain-2, one of the most promising targets for antimalarial drug design, plays a key role in parasite survival as a major peptide hydrolase within the hemoglobin degradation pathway. In this work, a series of novel dihydroartemisinin derivatives based...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yang, Cui, Kunqiang, Lu, Weiqiang, Luo, Wei, Wang, Jian, Huang, Jin, Guo, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264262/ https://www.ncbi.nlm.nih.gov/pubmed/21629181 http://dx.doi.org/10.3390/molecules16064527

Ejemplares similares

Artemisinin and the Derivatives Play Novel Role in Treatment for Graves’ Orbitopathy as Conventional Antimalarials
por: Guo, Yan, et al.
Publicado: (2021)

Artemisinin Antimalarials: Preserving the “Magic Bullet”
por: Maude, Richard J, et al.
Publicado: (2010)

DNA binding by the antimalarial compound artemisinin
por: Slavkovic, Sladjana, et al.
Publicado: (2022)

Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin
por: Park, Gab-Man, et al.
Publicado: (2017)

Anticancer Effect of AntiMalarial Artemisinin Compounds
por: Das, AK
Publicado: (2015)

Drug resistance genomics of the antimalarial drug artemisinin
por: Winzeler, Elizabeth A, et al.
Publicado: (2014)

Redetermination of dihydroartemisinin at 103 (2) K
por: Jasinski, Jerry P., et al.
Publicado: (2007)

Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs
por: Qiu, Feifei, et al.
Publicado: (2021)

In Vitro and In Silico Antimalarial Evaluation of FM-AZ, a New Artemisinin Derivative
por: Tsamesidis, Ioannis, et al.
Publicado: (2022)

Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin
por: Urban, Nicole, et al.
Publicado: (2020)

Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities
por: Wu, Yuet, et al.
Publicado: (2018)

A plausible mechanism for the antimalarial activity of artemisinin: A computational approach
por: Shandilya, Ashutosh, et al.
Publicado: (2013)

A SAR and QSAR Study of New Artemisinin Compounds with Antimalarial Activity
por: Santos, Cleydson Breno R., et al.
Publicado: (2013)

Potent in vivo antimalarial activity of water-soluble artemisinin nano-preparations
por: Valissery, Praveesh, et al.
Publicado: (2020)

Artemisinin Combination Therapy: A Good Antimalarial, but Is the Dose Right?
por: Garner, Paul
Publicado: (2013)

Stable Production of the Antimalarial Drug Artemisinin in the Moss Physcomitrella patens
por: Khairul Ikram, Nur Kusaira Binti, et al.
Publicado: (2017)

FABRICATION AND EVALUATION OF SMART NANOCRYSTALS OF ARTEMISININ FOR ANTIMALARIAL AND ANTIBACTERIAL EFFICACY.
por: Shah, Syed Muhammad Hassan, et al.
Publicado: (2016)

Split dosing of artemisinins does not improve antimalarial therapeutic efficacy
por: White, N. J., et al.
Publicado: (2017)

Antimalarial and anticancer properties of artesunate and other artemisinins: current development
por: Khanal, Pitambar
Publicado: (2021)

Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives
por: O’Flaherty, Katherine, et al.
Publicado: (2019)

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
por: Crespo-Ortiz, Maria P., et al.
Publicado: (2012)

Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline
por: Palla, Despina, et al.
Publicado: (2020)

Synthesis and anti-glioblastoma effects of artemisinin-isothiocyanate derivatives
por: Nyein, Chan Myae, et al.
Publicado: (2018)

The Antagonizing Role of Heme in the Antimalarial Function of Artemisinin: Elevating Intracellular Free Heme Negatively Impacts Artemisinin Activity in Plasmodium falciparum
por: Zhu, Pan, et al.
Publicado: (2022)

Evaluation of the Quality of Artemisinin-Based Antimalarial Medicines Distributed in Ghana and Togo
por: Osei-Safo, Dorcas, et al.
Publicado: (2014)

Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance
por: Heller, Laura E., et al.
Publicado: (2019)

Preventing antimalarial drug resistance with triple artemisinin-based combination therapies
por: Nguyen, Tran Dang, et al.
Publicado: (2023)

Post-marketing assessment of content and efficacy of preservatives in artemisinin-derived antimalarial dry suspensions for paediatric use
por: Atemnkeng, Magnus A, et al.
Publicado: (2007)

Structure–Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of rac-5β-Hydroxy-d-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action
por: Jahan, Mohamed, et al.
Publicado: (2021)

Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives
por: Saini, Deepika, et al.
Publicado: (2016)

Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites
por: Muangphrom, Paskorn, et al.
Publicado: (2016)

Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis
por: Saito, Makoto, et al.
Publicado: (2023)

Induction of autophagy and autophagy‐dependent apoptosis in diffuse large B‐cell lymphoma by a new antimalarial artemisinin derivative, SM1044
por: Cheng, Chunyan, et al.
Publicado: (2017)

Antimalarial activity of Garcinia mangostana L rind and its synergistic effect with artemisinin in vitro
por: Tjahjani, Susy
Publicado: (2017)

Transmission of Artemisinin-Resistant Malaria Parasites to Mosquitoes under Antimalarial Drug Pressure
por: Witmer, Kathrin, et al.
Publicado: (2020)

New Potential Antimalarial Agents: Design, Synthesis and Biological Evaluation of Some Novel Quinoline Derivatives as Antimalarial Agents
por: Radini, Ibrahim Ali M., et al.
Publicado: (2016)

Efficacy and safety of artemisinin-based antimalarial in the treatment of uncomplicated malaria in children in southern Tanzania
por: Kabanywanyi, Abdunoor M, et al.
Publicado: (2007)

Simple Field Assays to Check Quality of Current Artemisinin-Based Antimalarial Combination Formulations
por: Ioset, Jean-Robert, et al.
Publicado: (2009)

Repurposing Quinoline and Artemisinin Antimalarials as Therapeutics for SARS-CoV-2: Rationale and Implications
por: Firestone, Tessa M., et al.
Publicado: (2021)

Population Pharmacokinetics of Antimalarial Naphthoquine in Combination with Artemisinin in Tanzanian Children and Adults: Dose Optimization
por: Ali, Ali Mohamed, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_blpjko8k3sl2qnb6puqlhe3ba4