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Photochemical Synthesis of Nucleoside Analogues from Cyclobutanones: Bicyclic and Isonucleosides

The preparation of two nucleoside analogues are reported. Both syntheses involve a key photochemical ring-expansion of cyclobutanones to an oxacarbene and its subsequent scavenging by 6-chloropurine. The synthesis of a bicyclic (locked) purine starts from a oxabicycloheptanone with a hydroxymethyl p...

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Detalles Bibliográficos
Autores principales: Jaffer, Mileina, Ebead, Abdelaziz, Lee-Ruff, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264288/
https://www.ncbi.nlm.nih.gov/pubmed/20657410
http://dx.doi.org/10.3390/molecules15063816