Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives

New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell...

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Autores principales: Pertino, Mariano Walter, Theoduloz, Cristina, Palenzuela, Jose Antonio, del Mar Afonso, Maria, Yesilada, Erdem, Monsalve, Francisco, González, Paulo, Droguett, Daniel, Schmeda-Hirschmann, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264310/
https://www.ncbi.nlm.nih.gov/pubmed/21996716
http://dx.doi.org/10.3390/molecules16108614
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author Pertino, Mariano Walter
Theoduloz, Cristina
Palenzuela, Jose Antonio
del Mar Afonso, Maria
Yesilada, Erdem
Monsalve, Francisco
González, Paulo
Droguett, Daniel
Schmeda-Hirschmann, Guillermo
author_facet Pertino, Mariano Walter
Theoduloz, Cristina
Palenzuela, Jose Antonio
del Mar Afonso, Maria
Yesilada, Erdem
Monsalve, Francisco
González, Paulo
Droguett, Daniel
Schmeda-Hirschmann, Guillermo
author_sort Pertino, Mariano Walter
collection PubMed
description New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
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spelling pubmed-62643102018-12-10 Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives Pertino, Mariano Walter Theoduloz, Cristina Palenzuela, Jose Antonio del Mar Afonso, Maria Yesilada, Erdem Monsalve, Francisco González, Paulo Droguett, Daniel Schmeda-Hirschmann, Guillermo Molecules Article New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells. MDPI 2011-10-13 /pmc/articles/PMC6264310/ /pubmed/21996716 http://dx.doi.org/10.3390/molecules16108614 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pertino, Mariano Walter
Theoduloz, Cristina
Palenzuela, Jose Antonio
del Mar Afonso, Maria
Yesilada, Erdem
Monsalve, Francisco
González, Paulo
Droguett, Daniel
Schmeda-Hirschmann, Guillermo
Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
title Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
title_full Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
title_fullStr Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
title_full_unstemmed Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
title_short Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
title_sort synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264310/
https://www.ncbi.nlm.nih.gov/pubmed/21996716
http://dx.doi.org/10.3390/molecules16108614
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