Design, Synthesis and Biological Activity Evaluation of Arylpiperazine Derivatives for the Treatment of Neuropathic Pain

In this work, a series of arylpiperazine derivatives were synthesized and screened by in vivo pharmacological trials. Among the tested compounds, 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-1-phenylethanone (18) and 2-(4-(2,3-dimethylphenyl)piperazin-1-yl)-1-phenylethanone (19) exhibited potent...

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Detalles Bibliográficos
Autores principales: Chen, Yin, Wang, Guan, Xu, Xiangqing, Liu, Bi-Feng, Li, Jianqi, Zhang, Guisen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264349/
https://www.ncbi.nlm.nih.gov/pubmed/21738106
http://dx.doi.org/10.3390/molecules16075785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264349/
https://www.ncbi.nlm.nih.gov/pubmed/21738106
http://dx.doi.org/10.3390/molecules16075785

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