Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters

A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivitie...

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Detalles Bibliográficos
Autores principales: Yamamoto, Yasunori, Shirai, Tomohiko, Watanabe, Momoko, Kurihara, Kazunori, Miyaura, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264355/
https://www.ncbi.nlm.nih.gov/pubmed/21694668
http://dx.doi.org/10.3390/molecules16065020
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author Yamamoto, Yasunori
Shirai, Tomohiko
Watanabe, Momoko
Kurihara, Kazunori
Miyaura, Norio
author_facet Yamamoto, Yasunori
Shirai, Tomohiko
Watanabe, Momoko
Kurihara, Kazunori
Miyaura, Norio
author_sort Yamamoto, Yasunori
collection PubMed
description A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivities.
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spelling pubmed-62643552018-12-10 Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters Yamamoto, Yasunori Shirai, Tomohiko Watanabe, Momoko Kurihara, Kazunori Miyaura, Norio Molecules Article A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivities. MDPI 2011-06-17 /pmc/articles/PMC6264355/ /pubmed/21694668 http://dx.doi.org/10.3390/molecules16065020 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yamamoto, Yasunori
Shirai, Tomohiko
Watanabe, Momoko
Kurihara, Kazunori
Miyaura, Norio
Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters
title Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters
title_full Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters
title_fullStr Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters
title_full_unstemmed Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters
title_short Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters
title_sort ru/me-bipam-catalyzed asymmetric addition of arylboronic acids to aliphatic aldehydes and α-ketoesters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264355/
https://www.ncbi.nlm.nih.gov/pubmed/21694668
http://dx.doi.org/10.3390/molecules16065020
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