Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives

A series of N-methyl-4-phenoxypicolinamide derivatives were synthesized and evaluated in vitro for their cytotoxic activity against A549, H460 and HT29 cell lines. Pharmacological data indicated that some of the target compounds possessed marked antiproliferative activity, superior to that of the re...

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Autores principales: Li, Wei, Zhai, Xin, Ding, Lu, Sun, Limin, Chen, Xiaomei, Gong, Ping, Sun, Tiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264436/
https://www.ncbi.nlm.nih.gov/pubmed/21694676
http://dx.doi.org/10.3390/molecules16065130
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author Li, Wei
Zhai, Xin
Ding, Lu
Sun, Limin
Chen, Xiaomei
Gong, Ping
Sun, Tiemin
author_facet Li, Wei
Zhai, Xin
Ding, Lu
Sun, Limin
Chen, Xiaomei
Gong, Ping
Sun, Tiemin
author_sort Li, Wei
collection PubMed
description A series of N-methyl-4-phenoxypicolinamide derivatives were synthesized and evaluated in vitro for their cytotoxic activity against A549, H460 and HT29 cell lines. Pharmacological data indicated that some of the target compounds possessed marked antiproliferative activity, superior to that of the reference drug sorafenib. As the most promising compound, 8e exhibited potent cytotoxicity with the IC(50) value of 3.6, 1.7 and 3.0 μM against A549, H460 and HT-29 cell lines, respectively.
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spelling pubmed-62644362018-12-10 Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives Li, Wei Zhai, Xin Ding, Lu Sun, Limin Chen, Xiaomei Gong, Ping Sun, Tiemin Molecules Article A series of N-methyl-4-phenoxypicolinamide derivatives were synthesized and evaluated in vitro for their cytotoxic activity against A549, H460 and HT29 cell lines. Pharmacological data indicated that some of the target compounds possessed marked antiproliferative activity, superior to that of the reference drug sorafenib. As the most promising compound, 8e exhibited potent cytotoxicity with the IC(50) value of 3.6, 1.7 and 3.0 μM against A549, H460 and HT-29 cell lines, respectively. MDPI 2011-06-20 /pmc/articles/PMC6264436/ /pubmed/21694676 http://dx.doi.org/10.3390/molecules16065130 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Wei
Zhai, Xin
Ding, Lu
Sun, Limin
Chen, Xiaomei
Gong, Ping
Sun, Tiemin
Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives
title Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives
title_full Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives
title_fullStr Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives
title_full_unstemmed Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives
title_short Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives
title_sort synthesis and cytotoxic evaluation of novel n-methyl-4-phenoxypicolinamide derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264436/
https://www.ncbi.nlm.nih.gov/pubmed/21694676
http://dx.doi.org/10.3390/molecules16065130
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