A QM/MM–Based Computational Investigation on the Catalytic Mechanism of Saccharopine Reductase

Saccharopine reductase from Magnaporthe grisea, an NADPH-containing enzyme in the α-aminoadipate pathway, catalyses the formation of saccharopine, a precursor to L-lysine, from the substrates glutamate and α-aminoadipate-δ-semialdehyde. Its catalytic mechanism has been investigated using quantum mec...

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Detalles Bibliográficos
Autores principales: Joel N., Almasi, Eric A.C., Bushnell, Gauld, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264447/
https://www.ncbi.nlm.nih.gov/pubmed/21993247
http://dx.doi.org/10.3390/molecules16108569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264447/
https://www.ncbi.nlm.nih.gov/pubmed/21993247
http://dx.doi.org/10.3390/molecules16108569

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