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Synthesis and Cytotoxic Activity of Some New 2,6-Substituted Purines
A seriesof twenty four acyclic unsaturated 2,6-substututed purines 5a-20b were synthesized. These compounds were evaluated for cytotoxic activity against NCI-60 DTP human tumor cell line screen at 10µM concentration. N(9)-[(Z)-4'-chloro-2'-butenyl-1'-yl]-2,6-dichloropurine(5a), N(9)-[...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264448/ https://www.ncbi.nlm.nih.gov/pubmed/21747338 http://dx.doi.org/10.3390/molecules16075840 |