Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)

5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet), an indole-3-carbinol (I3C) metabolite endowed with anticancer properties, is poorly soluble in the solvents most frequently used in biological tests. This study indicates that the use of γ-cyclodextrin (γ-...

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Autores principales: Lucarini, Simone, Santi, Mauro De, Antonietti, Francesca, Brandi, Giorgio, Diamantini, Giuseppe, Fraternale, Alessandra, Paoletti, Maria Filomena, Tontini, Andrea, Magnani, Mauro, Duranti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264452/
https://www.ncbi.nlm.nih.gov/pubmed/20657428
http://dx.doi.org/10.3390/molecules15064085
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author Lucarini, Simone
Santi, Mauro De
Antonietti, Francesca
Brandi, Giorgio
Diamantini, Giuseppe
Fraternale, Alessandra
Paoletti, Maria Filomena
Tontini, Andrea
Magnani, Mauro
Duranti, Andrea
author_facet Lucarini, Simone
Santi, Mauro De
Antonietti, Francesca
Brandi, Giorgio
Diamantini, Giuseppe
Fraternale, Alessandra
Paoletti, Maria Filomena
Tontini, Andrea
Magnani, Mauro
Duranti, Andrea
author_sort Lucarini, Simone
collection PubMed
description 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet), an indole-3-carbinol (I3C) metabolite endowed with anticancer properties, is poorly soluble in the solvents most frequently used in biological tests. This study indicates that the use of γ-cyclodextrin (γ-CD) avoids this problem. Formulated with γ-CD CTet is a potent inhibitor of DNA synthesis in both estrogen receptor positive (MCF-7) and estrogen receptor negative (MDA-MB-231) human breast cell lines (IC(50) = 1.20 ± 0.04 μM and 1.0 ± 0.1 μM, respectively).
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spelling pubmed-62644522018-12-04 Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet) Lucarini, Simone Santi, Mauro De Antonietti, Francesca Brandi, Giorgio Diamantini, Giuseppe Fraternale, Alessandra Paoletti, Maria Filomena Tontini, Andrea Magnani, Mauro Duranti, Andrea Molecules Article 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet), an indole-3-carbinol (I3C) metabolite endowed with anticancer properties, is poorly soluble in the solvents most frequently used in biological tests. This study indicates that the use of γ-cyclodextrin (γ-CD) avoids this problem. Formulated with γ-CD CTet is a potent inhibitor of DNA synthesis in both estrogen receptor positive (MCF-7) and estrogen receptor negative (MDA-MB-231) human breast cell lines (IC(50) = 1.20 ± 0.04 μM and 1.0 ± 0.1 μM, respectively). MDPI 2010-06-04 /pmc/articles/PMC6264452/ /pubmed/20657428 http://dx.doi.org/10.3390/molecules15064085 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lucarini, Simone
Santi, Mauro De
Antonietti, Francesca
Brandi, Giorgio
Diamantini, Giuseppe
Fraternale, Alessandra
Paoletti, Maria Filomena
Tontini, Andrea
Magnani, Mauro
Duranti, Andrea
Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)
title Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)
title_full Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)
title_fullStr Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)
title_full_unstemmed Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)
title_short Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24-Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)
title_sort synthesis and biological evaluation of a γ-cyclodextrin-based formulation of the anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (ctet)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264452/
https://www.ncbi.nlm.nih.gov/pubmed/20657428
http://dx.doi.org/10.3390/molecules15064085
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