Discovery of Potential M2 Channel Inhibitors Based on the Amantadine Scaffold via Virtual Screening and Pharmacophore Modeling

The M2 channel protein on the influenza A virus membrane has become the main target of the anti-flu drugs amantadine and rimantadine. The structure of the M2 channel proteins of the H3N2 (PDB code 2RLF) and 2009-H1N1 (Genbank accession number GQ385383) viruses may help researchers to solve the drug-...

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Detalles Bibliográficos
Autores principales: Tran, Linh, Choi, Sy Bing, Al-Najjar, Belal O., Yusuf, Muhammad, Wahab, Habibah A., Le, Ly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264534/
https://www.ncbi.nlm.nih.gov/pubmed/22158591
http://dx.doi.org/10.3390/molecules161210227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264534/
https://www.ncbi.nlm.nih.gov/pubmed/22158591
http://dx.doi.org/10.3390/molecules161210227

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