Cargando…

Inhibitory Activity of Flavonoids against Class I Phosphatidylinositol 3-Kinase Isoforms

Class I PI3 Kinase (PI3K) phosphorylates phosphatidylinositol 4,5-bisphophate (PIP2) to generate the second messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3) and therefore plays an important role in fundamental cellular responses such as proliferation. There are four isoforms of class I PI3K...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Dexin, Zhang, Yanwen, Yamori, Takao, Duan, Hongquan, Jin, Meihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264676/ https://www.ncbi.nlm.nih.gov/pubmed/21694679 http://dx.doi.org/10.3390/molecules16065159

Ejemplares similares

Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy
por: Zhao, Wennan, et al.
Publicado: (2017)

Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking
por: Yoshioka, Kazuaki
Publicado: (2021)

Antiproliferative and Antiangiogenic Activities of Smenospongine, a Marine Sponge Sesquiterpene Aminoquinone
por: Kong, Dexin, et al.
Publicado: (2011)

ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells
por: Wang, Yaochen, et al.
Publicado: (2016)

Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS
por: Akashi, Tetsuyuki, et al.
Publicado: (2009)

In Vitro Antimetastatic Effect of Phosphatidylinositol 3-Kinase Inhibitor ZSTK474 on Prostate Cancer PC3 Cells
por: Zhao, Wennan, et al.
Publicado: (2013)

Analysis of some flavonoids for inhibitory mechanism against cancer target phosphatidylinositol 3-kinase (PI3K) using computational tool
por: Suhail, Mohd, et al.
Publicado: (2023)

Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 Cells
por: Jin, Meihua, et al.
Publicado: (2011)

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
por: Vieira, Otilia V., et al.
Publicado: (2001)

Inhibitory influence of natural flavonoids on human protein kinase CK2 isoforms: effect of the regulatory subunit
por: Baier, Andrea, et al.
Publicado: (2017)

The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells
por: Ivison, Sabine M., et al.
Publicado: (2010)

Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase
por: Luo, Yongjie, et al.
Publicado: (2016)

Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice
por: Islam, Shahidul, et al.
Publicado: (2020)

Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells
por: Gupta, Vivek K, et al.
Publicado: (2015)

Class IA Phosphatidylinositol 3-Kinase p110α Regulates Phagosome Maturation
por: Thi, Emily P., et al.
Publicado: (2012)

Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474
por: Isoyama, Sho, et al.
Publicado: (2015)

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
por: Birgisdottir, Åsa Birna, et al.
Publicado: (2019)

Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α
por: Sasaki, Junko, et al.
Publicado: (2005)

Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO
por: Reidick, Christina, et al.
Publicado: (2014)

Idelalisib: The First-in-Class Phosphatidylinositol 3-Kinase Inhibitor for Relapsed CLL, SLL, and Indolent NHL
por: Forcello, Nicholas, et al.
Publicado: (2014)

The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma
por: Pridham, Kevin J., et al.
Publicado: (2017)

Role of class III phosphatidylinositol 3-kinase during programmed nuclear death of Tetrahymena thermophila
por: Akematsu, Takahiko, et al.
Publicado: (2014)

Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex
por: Brier, Livia W., et al.
Publicado: (2019)

The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation
por: Xie, Bin, et al.
Publicado: (2021)

The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication
por: Delang, Leen, et al.
Publicado: (2012)

Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice
por: Toyama, Shoko, et al.
Publicado: (2010)

Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica
por: Nakada-Tsukui, Kumiko, et al.
Publicado: (2019)

In Vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells
por: Tang, Sheng-An, et al.
Publicado: (2014)

The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy
por: Dou, Zhixun, et al.
Publicado: (2010)

Insulin-Stimulated Degradation of Apolipoprotein B100: Roles of Class II Phosphatidylinositol-3-Kinase and Autophagy
por: Andreo, Ursula, et al.
Publicado: (2013)

Class III phosphatidylinositol 3-kinase complex I subunit NRBF2/Atg38 - from cell and structural biology to health and disease
por: Ohashi, Yohei
Publicado: (2021)

Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain
por: Volpicelli-Daley, Laura A., et al.
Publicado: (2010)

Rational Design and Synthesis of D‐galactosyl Lysophospholipids as Selective Substrates and non‐ATP‐competitive Inhibitors of Phosphatidylinositol Phosphate Kinases
por: Sun, Mengxia, et al.
Publicado: (2022)

Targeting Type Iγ Phosphatidylinositol Phosphate Kinase Inhibits Breast Cancer Metastasis
por: Chen, Chunhua, et al.
Publicado: (2014)

Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers
por: Anthony, Nahoum G., et al.
Publicado: (2017)

TAPBPR isoforms exhibit altered association with MHC class I
por: Porter, Keith M, et al.
Publicado: (2014)

Analysis of the Synaptotagmin Family during Reconstituted Membrane Fusion: UNCOVERING A CLASS OF INHIBITORY ISOFORMS
por: Bhalla, Akhil, et al.
Publicado: (2008)

Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement
por: Lacalle, Rosa Ana, et al.
Publicado: (2007)

Type Iγ phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration
por: Sun, Yue, et al.
Publicado: (2007)

Targeting type Iγ phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer
por: Yu, Minhao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c6ljolhsr1edq18slcvvage2o9