Novel Pyrazolo[3,4-d]pyrimidine Derivatives as Potential Antitumor Agents: Exploratory Synthesis, Preliminary Structure-Activity Relationships, and in Vitro Biological Evaluation

In a cell-based screen of novel anticancer agents, the hit compound 1a which bears a pyrazolo[3,4-d]pyrimidine scaffold exhibited high inhibitory activity against a panel of four different types of tumor cell lines. In particular, the IC(50) for A549 cells was 2.24 µM, compared with an IC(50) of 9.2...

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Detalles Bibliográficos
Autores principales: He, Hai-Yun, Zhao, Jin-Ni, Jia, Ruo, Zhao, Ying-Lan, Yang, Sheng-Yong, Yu, Luo-Ting, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264756/
https://www.ncbi.nlm.nih.gov/pubmed/22186955
http://dx.doi.org/10.3390/molecules161210685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264756/
https://www.ncbi.nlm.nih.gov/pubmed/22186955
http://dx.doi.org/10.3390/molecules161210685

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