The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells

Fifteen novel glycyrrhetinic acid derivatives containing a nitrogen heterocycle at C-30 and with different A-ring substituents were designed and synthesized. All of these derivatives have improved antiproliferative effects against human HL-60 leukemia cells. Compounds with a cyano-enone functionalit...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Guo, Xin, Li, Xiaojing, Liu, Dan, Song, Dandan, Xu, Ye, Sun, Ming, Jing, Yongkui, Zhao, Linxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264780/
https://www.ncbi.nlm.nih.gov/pubmed/20657452
http://dx.doi.org/10.3390/molecules15064439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264780/
https://www.ncbi.nlm.nih.gov/pubmed/20657452
http://dx.doi.org/10.3390/molecules15064439

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