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Examining the current standards for genetic discovery and replication in the era of mega-biobanks
With the recent deluge of mega-biobank data, it is time to revisit what constitutes “replication” for genome-wide association studies. Many replication samples are unavailable or underpowered, therefore alternatives beyond strict statistical replication are needed until the required resources become...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265242/ https://www.ncbi.nlm.nih.gov/pubmed/30498205 http://dx.doi.org/10.1038/s41467-018-07348-x |
| Sumario: | With the recent deluge of mega-biobank data, it is time to revisit what constitutes “replication” for genome-wide association studies. Many replication samples are unavailable or underpowered, therefore alternatives beyond strict statistical replication are needed until the required resources become available. |
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