Examining the current standards for genetic discovery and replication in the era of mega-biobanks

With the recent deluge of mega-biobank data, it is time to revisit what constitutes “replication” for genome-wide association studies. Many replication samples are unavailable or underpowered, therefore alternatives beyond strict statistical replication are needed until the required resources become...

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Detalles Bibliográficos
Autor principal: Huffman, J. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265242/
https://www.ncbi.nlm.nih.gov/pubmed/30498205
http://dx.doi.org/10.1038/s41467-018-07348-x
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author Huffman, J. E.
author_facet Huffman, J. E.
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description With the recent deluge of mega-biobank data, it is time to revisit what constitutes “replication” for genome-wide association studies. Many replication samples are unavailable or underpowered, therefore alternatives beyond strict statistical replication are needed until the required resources become available.
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spelling pubmed-62652422018-12-03 Examining the current standards for genetic discovery and replication in the era of mega-biobanks Huffman, J. E. Nat Commun Comment With the recent deluge of mega-biobank data, it is time to revisit what constitutes “replication” for genome-wide association studies. Many replication samples are unavailable or underpowered, therefore alternatives beyond strict statistical replication are needed until the required resources become available. Nature Publishing Group UK 2018-11-29 /pmc/articles/PMC6265242/ /pubmed/30498205 http://dx.doi.org/10.1038/s41467-018-07348-x Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Huffman, J. E.
Examining the current standards for genetic discovery and replication in the era of mega-biobanks
title Examining the current standards for genetic discovery and replication in the era of mega-biobanks
title_full Examining the current standards for genetic discovery and replication in the era of mega-biobanks
title_fullStr Examining the current standards for genetic discovery and replication in the era of mega-biobanks
title_full_unstemmed Examining the current standards for genetic discovery and replication in the era of mega-biobanks
title_short Examining the current standards for genetic discovery and replication in the era of mega-biobanks
title_sort examining the current standards for genetic discovery and replication in the era of mega-biobanks
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265242/
https://www.ncbi.nlm.nih.gov/pubmed/30498205
http://dx.doi.org/10.1038/s41467-018-07348-x
work_keys_str_mv AT huffmanje examiningthecurrentstandardsforgeneticdiscoveryandreplicationintheeraofmegabiobanks

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