Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma

Cellular senecence is an important biologic endpoint. Naturally occuring (aging) senescence is common in uterine leiomyoma (ULM). AKT is one of major pathways in promoting ULM growth and survial. Inactivation of AKT by MK2206 in ULM resulted in stress-induced senescence in vitro. Study of the senesc...

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Detalles Bibliográficos
Autores principales: Xie, Jia, Xu, Xiuhua, Yin, Ping, Li, Yinuo, Guo, Haiyang, Kujawa, Stacy, Chakravarti, Debabrata, Bulun, Serdar, Kim, J. Julie, Wei, Jian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265265/
https://www.ncbi.nlm.nih.gov/pubmed/30206313
http://dx.doi.org/10.1038/s41374-018-0117-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265265/
https://www.ncbi.nlm.nih.gov/pubmed/30206313
http://dx.doi.org/10.1038/s41374-018-0117-5

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