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Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma
Cellular senecence is an important biologic endpoint. Naturally occuring (aging) senescence is common in uterine leiomyoma (ULM). AKT is one of major pathways in promoting ULM growth and survial. Inactivation of AKT by MK2206 in ULM resulted in stress-induced senescence in vitro. Study of the senesc...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265265/ https://www.ncbi.nlm.nih.gov/pubmed/30206313 http://dx.doi.org/10.1038/s41374-018-0117-5 |